Testosterone replacement therapy: how to manage TRT safely

Think you might be suffering from low testosterone?

Average testosterone levels in men have more than halved over the past 50 years. The reason for this is not clear, but may be related to environmental toxins, obesity and diabetes.

Typical symptoms of low testosterone in men include some or all of the following:

  • Sexual function: Reduced interest in sex and erectile dysfunction.
  • Well-being: Lack of motivation, tiredness, poor sleep, depression and reduced self-confidence.
  • Physical changes: Loss of muscle and athletic performance, increased body fat, hot flushes and thinning of the bones.

Testing

These symptoms could be caused by many other conditions, so the first thing to do is have a blood test in the early morning (which is more accurate) to check your testosterone levels. If your doctor wants to rule out other possible causes, additional tests may be advised, such as a full blood count, liver and kidney function tests, thyroid function tests, etc.

Testosterone levels can vary significantly from day to day, so if the result is not clear, a second test is often done on another occasion to confirm the levels. Analysis of total testosterone gives an indication of your levels, but free testosterone, or preferably bioavailable testosterone, is more accurate, as it takes into account the part of the hormone that is bound to proteins and therefore inactive.

Testosterone deficiency levels are:

Total <300-350 ng/dL
Free <6.5-9 ng/dL
Bioavailable <1.1-1.3 ng/mL

If your testosterone levels are low, you may also be tested for LH, FSH and prolactin (other hormones involved), as well as having a blood count and a PSA test for prostate cancer.

If your testosterone levels are clearly normal, you should be assessed by your doctor to look for other possible causes of your symptoms.

Treatment

Before starting treatment, you need a general heart and blood pressure check and a rectal examination of the prostate to ensure there is no prostate cancer (which could be stimulated by the TRT).

In Spain, testosterone is available in two forms: a gel applied to the skin or an injection.

I usually suggest starting with the gel, as if you have any side effects, you can stop immediately, and it is out of your system in a day or two.

Some patients say they find the injections more effective. They are normally given into the muscle, typically every 2-4 weeks, according to the manufacturer’s recommendation. However, if the effects wear off before the next injection, it is possible to give smaller doses more frequently to obtain a steadier level in the body.

There is also a longer-acting version of injectable testosterone that lasts 10 to 14 weeks.

Benefits

Different effects of TRT may appear at different times.

Improvement in sexual drive, mood and quality of life starts within 3-6 weeks, whereas erectile function may take up to 6 months.

Changes in body fat, muscle mass and strength may take 3-4 months to become evident and continue to improve over the first year.

The best response is achieved with a combination of TRT and lifestyle changes, including exercise, diet, reducing alcohol consumption and smoking, and, if needed, additional medication such as tadalafil.

Monitoring

After three months, you should have another blood test to check the testosterone level. If using injectables, do the test halfway between injections to determine the average level. This, combined with your symptoms, determines whether the dose is right for you. The level should lie at the middle to upper end of the normal range. Don’t be tempted to push the level beyond the upper limit, as this carries risks to your health.

You must also check your blood count because TRT can stimulate an overproduction of red blood cells, which, if too high, carries a risk of stroke. If your haematocrit level is above 50%, you may need to reduce the dose. Above 54%, you may need to have 500 mL of blood removed (venesection) to quickly reduce the haematocrit.

A repeat rectal examination is done to check that the prostate has not grown or developed any nodules.

If all is well, a review six months later and then yearly is advised.

Side effects and risks

A small proportion of men experience acne or worsening of sleep apnoea.

Some men develop breast tenderness or swelling due to the conversion of testosterone to the female hormone oestrogen. Normally, this can be managed with oestrogen blockers.

Testicles tend to shrink as they are no longer needed to produce the body’s own testosterone.

Caution is required if there is a history of prostate problems or cardiovascular disease.

Fertility is an often-overlooked consideration. TRT reduces the sperm count. Even after stopping TRT, it may take many months to recover, and, rarely, infertility can be permanent.

If you are planning to have children in the future, you can discuss various options with your doctor, such as HCG injections (which stimulate your natural testosterone production) or sperm banking to safeguard fertility for the future.

How much does it cost?

Prices as of July 2026.

The initial consultation with a doctor at Atlantic Clinic is €90. Follow-up consultations are €60.

Examples of analysis costs:

Total testosterone €21
Bioavailable testosterone €65
Full blood count €11
PSA €23

We also offer analysis packages for check-ups. Find out more on our Analysis page.

Final thoughts

If you are weighing up the pros and cons of TRT, remember that low testosterone, if not corrected, carries its own health risks, apart from those mentioned above, such as diabetes, heart disease, strokes and reduced lifespan.

 

Dr Anthony Crichton-Smith

Dr Anthony Crichton-Smith | 10 July 2026

Meningitis B in the UK: What English Patients in Spain Need to Know

Recent news from the UK has highlighted a concerning outbreak of meningitis B (MenB) in Kent, England. While outbreaks of this kind remain rare, they serve as an important reminder of how serious this infection can be—and how valuable vaccination is in protecting yourself and your family.

At Atlantic clinic, we are already speaking with many British patients who either travel regularly to the UK or have children studying there. Here’s what you need to know.

A recent outbreak in the UK

In March 2026, health authorities identified a cluster of meningitis B cases centred around Canterbury in Kent. At the time of writing, there have been over 20 confirmed cases and several additional probable cases, with two tragic deaths reported.

The outbreak has mainly affected teenagers and young adults, particularly students, and has been linked to close-contact settings.

UK health officials responded quickly with antibiotics, contact tracing, and an expanded vaccination campaign targeting those at highest risk.

Although the situation is being brought under control, experts emphasise that meningitis can spread rapidly and unpredictably, and vigilance remains essential.

What is meningitis B?

Meningitis B is a serious bacterial infection caused by Neisseria meningitidis. It can lead to:

  • Meningitis (inflammation of the lining of the brain)
  • Sepsis (blood poisoning)

These conditions can develop quickly and may be life-threatening if not treated urgently.

While rare, MenB is the most common strain of meningococcal disease in the UK.

How is it spread?

Meningitis B is not highly contagious, but it spreads through close, prolonged contact, such as:

  • Living in the same household
  • Kissing
  • Sharing drinks, cigarettes, or vapes

This is why outbreaks are often seen in schools, universities, and social settings.

Symptoms to watch for

Early symptoms can be non-specific, but may include:

  • Fever
  • Headache
  • Vomiting
  • Neck stiffness
  • Sensitivity to light
  • Confusion
  • A rash that does not fade when pressed

Symptoms can worsen rapidly, so urgent medical attention is essential if meningitis is suspected.

Who is most at risk?

Higher-risk groups include:

  • Babies and young children
  • Teenagers and young adults (especially students)
  • People living in shared accommodation
  • Anyone in close contact with a confirmed case

Many adults and teenagers in the UK were never routinely vaccinated against MenB, as the vaccine was only introduced into the infant schedule in 2015.

The role of vaccination

The meningitis B vaccine provides important protection against this potentially life-threatening infection.

During the current outbreak, UK authorities have:

  • Offered vaccination to students and close contacts
  • Expanded eligibility to additional age groups in affected areas

This reflects the key role vaccination plays in controlling outbreaks and preventing severe illness.

Why this matters if you live in Spain

Even if you live on the Costa del Sol, or elsewhere in Spain, this issue is highly relevant if:

  • You travel regularly to the UK
  • Your children attend school or university there
  • You have family members in affected areas

Meningitis can spread through travel and social contact, so protection is not just a local issue.

Meningitis B vaccination in Marbella

At Atlantic clinic, we offer the meningitis B vaccine for both children and adults.

We commonly see:

  • Parents vaccinating teenagers before university
  • Families preparing for travel to the UK
  • Adults seeking added protection after hearing about recent outbreaks

Vaccination is a simple and effective step that can provide reassurance—especially during periods of increased risk.

For those never vaccinated, the complete course is 2 doses of the vaccine at least 1 month apart.

For those previously vaccinated, but at-risk, a single booster vaccine can be given.

The cost of each vaccine is 162€.

Final thoughts

The current UK outbreak is a reminder that while meningitis is uncommon, its impact can be severe and sudden.

If you or your family have connections to the UK, it may be worth considering vaccination—particularly for teenagers and young adults.

If you would like personalised advice or to book a meningitis B vaccine, our team at Atlantic Clinic is here to help.

 

For more information or appointments, please contact our clinic directly.

Call us (+34) 952 81 7425 or send a message (+34) 616 83 0988.

Why should we be vaccinating children against HPV?

Bérénice Ibarra Ottino

The Flu: All you need to know

The flu is a contagious respiratory disease. Caused by a virus, it is transmitted very easily through the air (coughing and sneezing), hands or through contaminated objects. To prevent its spread we must take some basic hygiene measures (hand washing, sneezing into the inner elbow or in a handkerchief, airing the house regularly, …).

There are several types of influenza viruses

As stated by the World Health Organization (WHO), there are four types of seasonal influenza virus: A, B, C and D.

– Types A and B are the cause of seasonal epidemics, hence they are included in vaccines.

-C viruses are detected less frequently and also cause only minor infections.

– Type D viruses do not affect humans, only cattle.

 

Is it necessary to get vaccinated every year?

The flu virus has a high mutation capacity and the types of flu viruses that circulate are changing from year to year. Thus, our defenses cannot recognize and protect us, which can cause disease again every new winter season.

For this reason, every year  a different vaccine is made, adapted to the changes that the virus has experienced and to those strains that are circulating. WHO, after studying the reports of epidemiological surveillance centers spread throughout the world, decides each year what will be the composition of vaccines to protect us in the most effective way.

 

What vaccines to choose?

In Spain, both trivalent influenza vaccines and tetravalent vaccines and only injectable preparations are available.

The difference between the trivalent flu vaccine and the tetravalent vaccine lies in the number of influenza virus strains included in it.

-The trivalent vaccine contains three strains every year: two of type A and one of type B.

-The tetravalent vaccine includes four: two of type A and two of type B, of which one is of the B / Victoria lineage and another of the B / Yamagata.

To an extent it is difficult to know in advance which lineage the B strains circulating during the season will belong to, but the tetravalent vaccine allows to increase the level of protection. In addition, tetravalent vaccines have shown in studies to be as safe as trivalent vaccines. This means that they can be used, both one and the other, in the same situations.

 

What vaccine is recommended to use?

Given the level of scientific evidence available, the AEP Vaccine Advisory Committee advises, preferably and whenever available, tetravalent influenza vaccines. Of course, if you do not have access to it, the recommendation is to administer trivalent vaccines.

 

Who should get vaccinated?

Children from 6 months to 4 years (59 months);
People 50 years of age and older (because they are more likely to suffer from chronic conditions that put them at high risk of presenting a serious case of influenza disease).
People with chronic lung diseases (such as asthma), heart disease (except hypertension), kidney, liver, hematological, neurological or metabolic disorders (including diabetes mellitus);
People immunosuppressed for any cause (including immunosuppression caused by medications or the human immunodeficiency virus);
Women who are pregnant or will be during the flu season and women who gave birth until two weeks ago;
Persons 6 months to 18 years of age who receive medications containing aspirin or salicylates and who are at risk of having Reye’s syndrome after influenza virus infection;
Residents of nursing homes and other chronic care facilities;
Native Americans / Alaska Natives
people with morbid obesity (body mass index [BMI] of 40 or higher);
health care staff;
People in contact with low mobility people at home and caregivers of children under 5 and adults over 50. Special emphasis on people who are in contact with children under 6 months or with people with certain medical conditions that put them at increased risk of serious complications from influenza.

 

 Special consideration about egg allergy

People allergic to eggs can receive any approved influenza vaccine recommended and according to their age (IIV, RIV4 or LAIV4). People with a clinical history of severe egg allergy (those who have had other symptoms besides hives after being exposed to eggs) should receive the influenza vaccine in a medical setting and under the supervision of a health care provider who is able to recognize and manage severe allergic reactions.

Bérénice Ibarra Ottino